Nasal Sprays

Nasal Sprays as a whole have not been widely studied for use in prevention of COVID-19 (yet). There have also been no comparative studies that can point to which type is most effective. Some studies that have been conducted and listed here have some issues; who they are funded by, methods carried out, etc. Be sure to check out the studies that are listed and use your best judgment to determine if this is worth adding to your toolbox.

Currently Available Nasal Sprays

  • Iota-Carrageenan Nasal Spray
  • Hypromellose spray
    • Definition: Hypromellose Spray changes the pH of the nasal cavity with an acidic gel layer that is shown to reduce risk of viral infection
    • Considerations:
      • Produced in Israel, so may violate BDS
    • Studies and information:
      • "Low pH Hypromellose (Taffix) nasal powder spray could reduce SARS-CoV-2 infection rate post mass-gathering event at a highly endemic community: an observational prospective open label user survey" (Expert Rev Anti Infect Ther. April 2021.)
    • Brands/Links to Buy
      • Taffix
  • Nitric Oxide spray
    • Definition: Destroys viruses and impedes viral replication in the nose. It has also been shown to block the ACE-2 receptor essential for the covid virus to infect cells.
    • Studies and information:
      • "Epidemiological Analysis of Nitric Oxide Nasal Spray (VirX™) Use in Students Exposed to COVID-19 Infected Individuals" (Miller and Moore. Spring 2023.)
      • "SARS-CoV-2 accelerated clearance using a novel nitric oxide nasal spray (NONS) treatment: A randomized trial" (Study. July 2022)
      • Current clinical trials for prevention due to finish Jan 2024
      • Video on how Nitric Oxide Spray may be used in the prevention of COVID-19(SaNOtize)
    • Brands/Links to buy:
  • Xylitol Nasal Spray
    • Definition: A natural virucidal agent that alters the optimal acidic environment required for cell invasion, preventing viral entry into the nasal epithelium
    • Studies and information:
      • "Evaluating the efficacy and safety of a novel prophylactic nasal spray in the prevention of SARS-CoV-2 infection: A multi-centre, double blind, placebo-controlled, randomised trial." (J Clin Virol. October 2022.)
    • Considerations:
  • Ethyl Lauroyl Arginate HCl

    Future Nasal Spray Technology Undergoing Trials/In Production

  • Trimeric Sherpabody 92 (TriSb92)
    • Definition: an engineered homotrimeric Sherpabody produced from E. coli.
    • Brands/Links to buy: